Table 4–3: µSM-FL maintenance procedures (continued)
Maintenance procedure Frequency
Replace the sample syringe As part of the annual scheduled routine
maintenance and thereafter, as needed.
These are the typical failure modes:
• The sample syringe leak test fails.
• Air bubbles are in the syringe.
• A sample syringe hardware error
message appears.
Replace the injection valve cartridge As needed.
Table 4–4: TVM maintenance procedures
Maintenance procedure Frequency
Replace the column As needed. The typical failure modes are as
follows:
• High back pressure: the column causes a
high-pressure shutdown.
• Method requirements are not met, as
evidenced by poor peak shape, resolution
between peaks lost, tailing, and so on.
Perform a plate count to establish column
efficiency.
Replace the valve cartridge As needed.
Clean the device’s exterior with a soft, lint-
free cloth, or paper dampened with water
Perform as part of annual routine scheduled
maintenance and when solvent or dust
accumulates.
4.3
Troubleshooting
When a malfunction occurs, you must systematically troubleshoot the system to isolate the
problem.
4.3.1
General principles
Follow these general principles for troubleshooting the ACQUITY UPLC M-Class system:
November 26, 2019, 715003588 Revision C
Page 63
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