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Operation of the Liberty Blue
Microwave Editor
The Microwave Editor allows for the control and customization of the microwave steps of any cycle. By editing
the power and duration of a microwave step, difcult peptides can be synthesized with higher purity and yield. The
Microwave Editor can be accessed from the Edit menu.
The specic microwave power setting required to obtain acceptable heating rates will vary from unit to unit. As
such, care must be taken to optimize the microwave settings.
There are two key times for optimal microwave heating:
• Ramp Time: This refers to the approximate time it takes to heat the reaction mixture from its starting
temperature to its desired temperature.
• Total Time: This refers to the total reaction time including both the ramp and hold time.
NOTE
It is important to note that the Liberty microwave methods are not programmed by specifying a set ramp
time. This term is only guidance for what should be observed when applying the method. The actual ramp
time is controlled by adjusting the MW power within each method. Default power settings are given that
serve as a starting point for optimizing the MW power settings.
Microwave Method Folders
The Microwave Editor contains a variety of optimized default microwave methods separated by scale and type
(deprotection or coupling).
Creating a New Microwave Method
Microwave Methods allow for detailed control of the microwave heating and reaction time for each step in the
synthesis. The Microwave Editor allows the user to select the microwave time, microwave power, maximum
temperature, and sample agitation.
To create a new Microwave Method:
1. Click on the lter buttons at the top of the Microwave Editor to open the lter list.
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