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Setting up a Synthesis
6. Connect the new vessel body to the attenuator.
7. Connect the ltered drain line to the new vessel body using the union, being careful not to cross
thread or over tighten the tting.
8. Place the vessel back into the microwave cavity, securing the attenuator.
5.1. Use Reagent Calculator to determine the amount of resin required for the synthesis.
5.2. Remove the reaction vessel from the microwave cavity.
5.3. Disconnect the ltered drain line from the vessel body using the union.
WARNING
The Liberty Blue reaction vessel is designed to work with 100-200 mesh resins only. The use of 200-400
mesh resins will clog the frit on the bottom of the reaction vessel, resulting in failure to drain the vessel
and a possible reaction vessel overow event.
5.4. Disconnect the vessel body from the attenuator.
5.5. Weigh the appropriate amount of dry resin (100-200) mesh into the vessel body.
5.6. Connect the vessel body to the attenuator.
5.7. Connect the ltered drain to the vessel body using the brown union.
5.8. Place the vessel back into the microwave cavity, securing the attenuator.
Running the Liberty Blue
Preparing the Liberty Blue to Run
1. Verify the level of the waste container to ensure there is sufcient room before starting another synthesis.
2. Verify the nitrogen supply to ensure there is sufcient nitrogen to complete the synthesis.
3. Verify that the ber optic probe is fully inserted into the thermowell.
WARNING
If the probe is not inserted all the way to the bottom of the vessel the Liberty Blue will not accurately
measure the temperature, and overheating of the vessel can occur. This will result in poor synthesis quality
and/or serious damage to the vessel.
4. Verify that the method is correct by looking at the steps outlined in the Method box. If there are any errors, make
corrections and reload the method.
4.1. Clear the method by clicking the small X at the top of the resin indicator.
4.2. To correct the method:
4.2.1 Open the Liberty Method Editor.
4.2.2 Open the folder where the method was saved, then click on the method to load it.
4.2.3 Make any corrections as needed and then click Save to save the method. Then, close the
Liberty Method Editor.
4.2.4 Load the corrected method as described above.
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