5.1.1 Column flow packing method
P
acking flow rate
Packing flow rates should be found in the leaflet supplied with the media. The optimum
packing flow rates is dependent on temperature, type of media,concentration and the
packing method. Consequently, the optimum flow rate or rates must be determined
empirically by producing a pressure/flow rate curve.
It is advisable to do a pressure flow curve with a similar volume media that will be
packed in the column.
Method description
Constant flow packing is a two step method that is applicable to all types of media.
Assuming a suitable liquid delivery system is available, the main requirements are that
the column must have a moveable adapter and a pressure rating which allows the
optimal packing flow rate to be obtained.
1. In the first step, a low flow rate is used to form a loosely packed bed from the slurry.
This allows the adapter to be lowered the majority of the distance towards its final
packed position with little or no expansion of the bed during travel time.
2. In the second step, the flow rate is increased to a predetermined optimal value to
obtain the desired packing density. When flow is stopped, the proximity of the
adapter to the bed minimizes the time necessary to successfully reposition the
adapter to stabilize the packed bed.
5 Operation
5
.1 Preparation
5.1.1 Column flow packing method
BPG Columns Operating Instructions 29193223 AB 49
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