OPTi CCA-TS2 User Manual

K-2 Operator’s Manual – OPTI CCA-TS2
POTASSIUM ANALYTES
Interferences
The OPTI CCA K
+
sensor has no measurable interference from Na
+
variation within the range 100-190
mmol/L.
The OPTI CCA K
+
results include an appropriate correction for pH at all values of pH.
This correction may introduce an extra source of variability at the extreme values.
The OPTI CCA K
+
sensor has no interference from ammonia or ammonium ion present at normal
physiologic levels (below 100 µmol/L). At hyperammonemia (plasma levels of 300 µmol/L),
the OPTI CCA K
+
sensor will show a potassium offset of +0.4 mmol/L, and at extreme hyperammonemia
(plasma levels of 3000 µmol/L), the OPTI CCA K
+
sensor will show a potassium offset of +4.4 mmol/L.
Heparin salts are the only acceptable anticoagulants. Other anticoagulants such as citrate, EDTA, oxalate,
and uoride cause signicant interferences to the electrolyte sensors.
The following exogenous interferents were quantied in tonometered plasma, showing interferences to
dyes which typically have short half-lives within the body before being metabolized by the liver.
This testing was done on the OPTI CCA platform, with a standard OPTI style Potassium sensor.
No changes were made to the sensor or the measurement principle, so the interference of the OPTI CCA-
TS2 is equivalent to the OPTI CCA.
Substance Amount K
+
change (mmol/L)
Sodium uorescein 26 mg/dL -0.7
Cardio (indocyanine) green 0.5 mg/dL -0.4
Methylene blue 25 mg/dL +2.4
Only clear, uncolored quality control materials, such as OPTI CHECK or OPTI CHECK PLUS brand
aqueous controls should be used with the OPTI CCA-TS2 system. Colored materials, including
prociency testing materials, may interfere with the potassium measurement, or fail to be properly
aspirated.
Reproducibility
Controls
Within run precision (S
wr
) and Total Precision (S
T
), were determined from 2 runs per day with 2 replicates
per run over a period of 20 days following the CLSI guideline EP5-A2. Typical results for 3 different
control levels are shown below.
K
+
(mmol/L) OPTI Check Level 1 OPTI Check Level 2 OPTI Check Level 3
Days Run 20 20 20
Total Average 2.92 4.86 5.92
Within Run St. Dev. (S
wr
) 0.03 0.03 0.03
Within Run % CV 0.9% 0.6% 0.5%
Total Precision St. Dev. (S
T
) 0.03 0.03 0.04
Total % CV 1.0% 0.6% 0.6%

OPTi CCA-TS2 Specifications

General

Brand	OPTi
Model	CCA-TS2
Category	Measuring Instruments
Language	English