Table C–1: Items exposed to solvent (KAD)
Item Material
Gas exhaust port Aluminum
Gas tubes FEP (fluorinated ethylene propylene)
Ion block Stainless steel
Ion block support PEEK (polyetheretherketone)
O-rings Viton or PTFE (polytetrafluoroethylene)-encapsulated Viton
Solvent waste/leak management Fluorinated ethyline polymer (FEP) tubing
Source enclosure Aluminum
Waste bottle Polypropylene
Pumping Block gaskets FEPM
Waste bottle push-in fittings NBR (nitrile butadiene rubber), SST (stainless steel), PBT
(polybutylene terephthalate), and POM (polyoxymethylene)
C.3.2 Solvents used to prepare mobile phases
The table below lists solvents and reagents used commonly to prepare mobile phase and, in
some cases, act as sample diluents. They are not expected to adversely affect the performance
of the materials shown in the table "Items exposed to solvent (KAD)" in Items exposed to solvent.
Note: The list of solvents and chemicals and their associated concentrations shown below
presents the levels that have been tested, assessed, or both, for chemical compatibility with the
materials of construction. It is not a recommendation for optimal electrospray sensitivity. Mobile-
phase component concentration affects electrospray efficiency and sensitivity. Keep modifier and
buffer concentrations to the lowest levels that maintain chromatographic resolution.
Notice: For LC/MS operation, do not prepare mobile phases using normal-phase
solvents like hexane. Such solvents adversely affect the performance of the materials
named in the list of items exposed to solvents (see Items exposed to solvent), and
should not be used except at or below the concentrations specified. In the event the
solvents are used at reduced concentrations as additives to mobile phases or as
sample diluents, you must evaluate the consequent compatibility issues.
Table C–2: Solvents used to prepare mobile phases (KAD)
Solution Concentration
Water 100%
Methanol 100%
Acetonitrile 100%
June 15, 2017, 715003956 Rev. F
Page 76
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