Waters ACQUITY - Cleaning the Ion Guide Assembly

9. Carefully remove the differential aperture from its vessel and blow-dry the component
using inert, oil-free gas.
10. Discard the used isopropyl alcohol, using an appropriate waste container.
3.10.3 Cleaning the ion guide assembly
Required materials
• Chemical-resistant, powder-free gloves
• Suitable vessel in which to completely immerse the ion guide assembly when cleaning
• Two lengths of PEEK, PTFE, or stainless steel tubing, appropriately sized for suspending the
ion guide assembly in the glass vessels when cleaning
• HPLC-grade deionized water
• Waters MS Cleaning Solution (186006846) or HPLC-grade (or better) 1:1 methanol/water
• Holding container for used Waters MS Cleaning Solution
• HPLC-grade isopropyl alcohol
• Ultrasonic bath
• Source of oil-free, inert gas (for example, nitrogen) for drying
Warning: To avoid personal contamination with biohazardous or toxic compounds, wear clean,
chemical-resistant, powder-free gloves when performing this procedure.
To clean the ion guide assembly:
1. Bend a PEEK, PTFE, or stainless steel tube into a hook shape and use to carefully
suspend the first ion guide PCB assembly in the glass vessel so that the bottom of the
assembly does not touch the bottom of the vessel.
Notice: To avoid damage to the ion guide caused by vibration, ensure that the
bottom of the ion guide does not touch the bottom of the glass vessel.
June 15, 2017, 715003956 Rev. F
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