Waters ACQUITY - Cleaning the Differential Aperture

Ion guide
Ion guide securing screws (fourth screw is obscured)
Differential aperture support
3.10.2 Cleaning the differential aperture
Required materials
• Chemical-resistant, powder-free gloves
• Suitable glass vessel in which to completely immerse the differential aperture when cleaning
• HPLC-grade deionized water
• Waters MS Cleaning Solution (186006846) or HPLC-grade (or better) 1:1 methanol/water
• Holding container for used cleaning solution
• Ultrasonic bath
• Source of oil-free, inert gas (for example, nitrogen) for drying
Warning: To avoid personal contamination with biohazardous or toxic compounds, wear clean,
chemical-resistant, powder-free gloves when performing this procedure.
To clean the differential aperture:
1. Place the differential aperture in the glass vessel.
2. Add Waters MS Cleaning Solution or 1:1 methanol/water to the vessel until the differential
aperture is immersed completely.
3. Place the vessel containing the differential aperture in the ultrasonic bath for 20 minutes.
4. Carefully pour the cleaning solution from the vessel holding the differential aperture into the
holding container, retaining the differential aperture in the vessel.
Tip: You can reuse Waters MS Cleaning Solution for one subsequent cleaning.
5. Fill the vessel with deionized water to rinse the differential aperture, and then discard the
water.
6. Refill the vessel with deionized water to rinse the differential aperture a second time, and
then discard the water.
7. Fill the vessel with isopropyl alcohol, ensuring that the differential aperture is immersed
completely.
8. Place the vessel containing the differential aperture in the ultrasonic bath for 20 minutes.
June 15, 2017, 715003956 Rev. F
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