Rev. Date: 12-Jul-11 Art: 714175-00K CL - 3
Method Comparison (mmol/L or mEq/L)
Beckman Synchron CX
®
3
Kodak Ektachem
700 Nova STAT Profile
®
5
n 189 142 192
Sxx 1.27 0.41 0.89
Syy 0.88 0.90 0.88
Slope 0.99 0.88 0.93
Int’t -0.82 14.6 4.3
Sy.x 1.65 1.84 2.33
Xmin 93 63 96
Xmax 114 128 117
r 0.817 0.914 0.752
Factors Affecting Results*
Hemodilution of the plasma by more than 20% associated with priming cardiopulmonary bypass pumps,
plasma volume expansion or other fluid administration therapies using certain solutions may cause clinically
significant error on sodium, chloride, ionized calcium and pH results. These errors are associated with
solutions that do not match the ionic characteristics of plasma. To avoid these errors when hemodiluting by
more than 20%, use physiologically balanced multi-electrolyte solutions containing low-mobility anions (e.g.
gluconate) such as Normosol
®
-R (Abbott Laboratories), Plasma-Lyte
®
-A (Baxter Healthcare Corporation),
and Isolyte
®
-S (B Braun Medical) rather than solutions such as normal saline or Ringer’s Lactate.
Test concentrations used were as per the CLSI guidance document,
7
unless otherwise indicated .
The following substances are known to interfere with the i-STAT chloride assay:
Substance
Test Concentration
(mmol/L)
Interference
Acetylcysteine 10.2
Decreased i-STAT Chloride results.
See Note below.
Bromide 37.5
Increased i-STAT Chloride results.
Use another method.
Bromide (therapeutic) 2.5
8,9,10
Increased i-STAT Chloride results.
Use another method.
Salicylate 4.34
Increased i-STAT Chloride results.
Use another method.
Thiocyanate 6.9
Increased i-STAT Chloride results.
Use another method.
The following substances are known not to significantly interfere with the i-STAT chloride assay at
the stated test concentrations:
Substance
Test Conc.
(mmol/L)
Acetaminophen 1.32
Acetylcysteine (therapeutic) 0.30
11,12,13
Ascorbate 0.34
β-Hydroxybuterate 6.0
14
Lactate 6.6
Salicylate (therapeutic) 0.5
15
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