Rev. Date: 23-May-12 Art: 716969-00J BNP - 13
Interference Testing
The following substances were found to have no significant effect (less than 10%) on the BNP method,
when added to a plasma pool containing approximately 1000 pg/mL of B-type natriuretic peptide at the
concentrations indicated:
Interference studies were based on CLSI guideline EP7-A.
36
Compound
Test Level
(μmol/L unless otherwise indicated)
Acetaminophen 1660
Allopurinol 294
Ampicillin 152
Ascorbic Acid 227
Acetyl Salicylic Acid 3330
Atenolol 37.6
Caffeine 308
Captopril 23
Chloramphenicol 155
Diclofenac 169
Digoxin 6.15
Dopamine 5.87
Enalaprilat 0.86
Erythromycin 81.6
Furosemide 181
Sodium Heparin 90 U/mL
Ibuprofen 2425
Isosorbide dinitrate 636
Methyldopa 71
Nicotine 6.2
Nifedipine 1156
Phenytoin 198
Propanolol 7.71
Salicylic Acid 4340
Theophylline 222
Verapamil 4.4
Warfarin 64.9
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