50
eRev. 1.08/15/2023
If problems arise that cannot be solved using the guidelines above, please reference the Repligen’s Analytics business Support Portal
or contact Support at the information below.
Support Portal: https://support.ctechnologiesinc.com/
Support line: US +1 908-707-1201
Support email: analytics-support@repligen.com
14.2 Maintenance and Best Practices
Repligen offers service contracts for on-site instrument qualification and preventative maintenance services.
IMPORTANT: The operator should not attempt to disassemble or open the individual instrument’s components under any
circumstances. Only Repligen analytical specialists or their qualified agents are trained to safely open and perform corrective
and preventative maintenance on the FlowVPX instrument.
Repligen recommends the following schedule for ensuring the FlowVPX System is operating optimally at all times:
Cleaning the Optical Path
Clean the optical path of the system weekly to ensure optimal light transmission.
• Use a lint-free wipe soaked in isopropyl alcohol (70%) to gently clean each optical surface listed.
• Wipe in a single direction.
• Follow with a dry wipe as needed.
1. Clean Delivery Fiber end faces if using the Cary 60 light source.
2. Clean the Fibrette Optical Component’s connection to Delivery Fiber if using the Cary 60 light source (soak wipe with 70%
isopropyl alcohol).
3. Clean Flow Cell’s internal surfaces.
4. Clean Flow Cell Window (soak wipe with 70% isopropyl alcohol).
5. Clean Detector Window (soak wipe with 70% isopropyl alcohol).
Restart the Cary 60
If using the Cary 60, restart the spectrophotometer once a week or between every process run.
Run a System Suitability Test
Check the raw transmission of the system using the transmission tool and run system suitability checks with ConfiRM slope
reference materials UV standards once a month.
Loading and Unloading the Flow Cell
1. Follow on-screen prompts whenever loading/unloading the Flow Cell to avoid damage to the equipment.
CAUTION: The FlowVPX instrument has not been validated for Steam-In-Place (SIP) processes while fully assembled.
Repligen recommends cleaning the Flow Cell in accordance with Flow Cell-specific limitations and while unloaded
from the FlowVPX Head and Detector. Excessive heat transfer to the FlowVPX Head or Detector will cause damage
to internal electronics.
CAUTION: Flow Cell Smart Pins electrical contacts are gold plated and susceptible to damage if cleaners are used on the
external surfaces of the FlowVPX hardware. It is recommended to clean the electrical contacts independently with
dry canned air or cotton swab, and then to cover them prior to any spray cleaning operations with any chemical
media.
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