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eRev. 1.08/15/2023
Flow Head: Another name for the FlowVPX instrument (excluding the Flow Cell, Flow Fibrette, and Detector Module), it is the key
component that enables the variable pathlength technology. Using the Cary 60 spectrophotometer as its power and light source, this
serves as the in-line material-measurement instrument that allows dynamic adjustment of the optical pathlength between 0.001
mm (1 micron) and 8.000 mm.
FX Connector Nut: Secures the FlowVPX Fibrette to the FlowVPX Head.
Measure: The criteria, metric, or means to which a comparison is made with output.
Measurement: The act or process of quantitatively comparing results with requirements.
Measurement Error: see Measurement Uncertainty.
Measurement System: All operations, procedures, devices, and other equipment or personnel used to assign a value to the
characteristic being measured.
Measurement Uncertainty: The result of random effects and imperfect correction of systemic effects in obtaining a measurement
value that results in variation from the actual true value; also known as measurement error.
Pathlength: The distance the measured light travels through the sample when making absorbance spectroscopy measurements
based on Beer-Lambert law. In the variable pathlength system, this distance, generally expressed in millimeters, is defined by the
physical gap between the bottom of the sample vessel containing the solution and the tip of the Fibrette that is submerged in the
sample.
Range: The measure of dispersion in a data set (the difference between the highest and lowest values).
Raw Transmission: A measurement of light passed from the light source though the delivery fiber directly to the instrument
detector.
Sample: A uniform lot of material that is to be analyzed. In spectroscopic quantitative analysis, samples are divided into two
categories: calibration samples and prediction samples. Calibration samples are split into at least two aliquots, one of which is sent
to a reference laboratory and the other read by the instrument; these are then combined into a calibration set for determining the
regression coefficients or calibration model.
Slope Spectroscopy®: An analytical technique based on Beer-Lambert law, which utilizes the slope term of a statistically analyzed
absorbance vs. pathlength plot to make calculations and predictions of sample properties.
Spectrophotometer: A device used to measure and record the spectrum of a material at uniform, usually closely spaced, wavelength
or wavenumber intervals. This type of instrument is sometimes referred to as a spectrometer, although correct terminology is
spectrophotometer. It is specifically designed to measure the ratio of the sample signal (I) versus the reference signal (I
0
) as the ratio
I/I
0
.
Smart Technology: A feature incorporated into the FlowVPX Head and measurement cells to communicate hardware status and
other information to the ViPER software.
System Suitability: Evaluates the components of the analytical system to show that the performance of the system meets the
standards required by the method.
Validation: The act of confirming that a product, process, or service meets the requirements for which it was intended.
VPT: Variable pathlength technology
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