Thermo Scientific TSQ Series Hardware Manual 1
Introduction
TSQ Series mass spectrometers are members of the Thermo Scientific family of mass
spectrometers. The TSQ Series mass spectrometer is an advanced analytical instrument that
includes a syringe pump, a divert/inject valve, a mass spectrometer, and a data system.
In a typical analysis, a sample can be introduced in the following ways:
• Using the syringe pump (direct infusion)
• Using the divert/inject valve fitted with a sample loop and liquid chromatograph (LC)
(flow injection analysis)
• Using the divert/inject valve and high-performance liquid chromatograph (HPLC) fitted
with a column (LC/MS)
In a typical analysis, an LC introduces a sample. The LC separates the sample into its various
components. The components elute from the LC and pass into the mass spectrometer where
they are analyzed.
Analysis by direct infusion or flow injection provides no chromatographic separation of
components in the sample before they pass into the mass spectrometer. The data from the
mass spectrometer is then stored and processed by the data system.
The TSQ mass spectrometer consists of an atmospheric pressure ionization (API) source, ion
optics, triple-stage mass analyzer, and ion detection system. A vacuum manifold encloses the
ion optics, mass analyzer, ion detection system, and part of the API source. Ionization of the
sample takes place in the API source. The specific process used to ionize the sample is known
Contents
• Ionization Modes
• Ion Polarity Modes
• Scan Modes
• Scan Types
• Data Types
• Mass/Charge Range
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