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Vacuum System
Atmospheric Pressure Ionization Source
Thermo Scientific Orbitrap Fusion Series Hardware Manual 23
Atmospheric Pressure Ionization Source
The atmospheric pressure ionization (API) source forms gas phase sample ions from sample
molecules that are contained in solution. The API source also serves as the interface between
the LC and the mass spectrometer. You can configure the EASY-Max NG API source, which
is provided with the mass spectrometer, for the following ionization techniques:
heated-electrospray (H-ESI), atmospheric pressure chemical ionization (APCI), and
atmospheric pressure photoionization (APPI).
The Orbitrap Fusion Series MS has a front, built-in drain that routes the solvent waste from
the API source to the solvent waste container connected to the back drain/waste port. For
information about the solvent waste connection, refer to the Orbitrap Fusion Series Getting
Connected Guide.
For information about the API source, refer to Chapter 2 in the Orbitrap Fusion Series Getting
Started Guide. For instructions on how to install the spray insert, refer to the Ion Max NG and
EASY-Max NG Ion Sources User Guide.
Figure 9. EASY-Max NG API source (H-ESI mode)
ESI spray insert
API source housing
Locking lever (locked position)
Sample inlet
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