Rev. Date: 03-Aug-12 Art: 714183-00T Crea - 5
5) Bromide has been tested at two levels; the CLSI recommended level and a therapeutic plasma con-
centration level of 2.5 mmol/L. The latter is the peak plasma concentration associated with halothane
anesthesia, in which bromide is released. APOC has not identified a therapeutic condition that would
lead to levels consistent with the CLSI recommended level. Bromide at a concentration of 37.5 mmol/L
increased i-STAT creatinine results, while a therapeutic range of bromide (2.5 mmol/L) did not significantly
interfere with i-STAT creatinine results.
6) The dependence of the i-STAT creatinine with respect to Carbon Dioxide (CO2) is as follows:
For Crea values below 2 mg/dL:
For PCO2 values above 40 mmHg, the values are increased by 6.9% for every 10 mmHg
For PCO2 values below 40 mmHg, the values are decreased by 6.9% for every 10 mmHg
[Cr]corrected = [Cr]istat X { 1 - ( 0.069 X [(PCO2 -40)/10]) }
For Crea values above 2 mg/dL:
For PCO2 values above 40, the values are decreased by 3.7% for every 10 mmHg
For PCO2 values below 40, the values are increased by 3.7% for every 10 mmHg
[Cr]corrected = [Cr]istat X { 1 - ( 0.037 X [(40 - PCO2 )/10]) }
*It is possible that other interfering substance may be encountered. The degree of interference at concentrations other than those listed might not be
predictable.
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