PN 177196BB
7-32
DATA MANAGEMENT AND REVIEW
DATA ANALYSIS REVIEW - PLATELET PARAMETERS
THREE HISTOGRAMS WITH INTRUSION ON UPPER END OF PLT DISTRIBUTION
Microcytic Interference with a Distinct Valley between 18 fL and 25 fL
1. If intrusion of microcytes creates a valley between
the 25 fL and the 18 fL thresholds, the 25 fL
threshold is repositioned at the valley to minimize
interference to platelet parameter results.
2. When this occurs, reported platelet result is
acceptable; however, MIC (microcytes) flag
appears to alert Operator that microcytes are
present.
Microcytic Interference with a Valley below 18 fL
1. If microcytes are extremely small so that the valley
between the platelet population and the microcyte
population falls below the 18 fL limit, the threshold
is placed at the 18 fL limit.
2. When this occurs, MIC flag appears and the
platelet count is flagged to alert the Operator that
the extremely small microcytes present in this
sample could not be eliminated.
3. Platelet count and associated parameters are not
reliable and should be verified by an alternative
method.
Interference with No Distinct Valley
1. Interference present in the upper area of the
platelet distribution curve blending with the
platelet population so that there is no clear
distinction between the platelets and the
interference suggests the presence of schistocytes
(fragmented red cells) or platelet aggregates
(platelet clumps).
2. If threshold cannot be positioned in the 25 fL to
18 fL region, threshold defaults to 18 fL position.
3. SCH (schistocytes) flag appears and the platelet
count is flagged to alert the Operator that the
interference (which is most likely either
schistocytes or platelet clumps) could not be
eliminated.
4. PLT count and associated parameters are not
reliable and must be verified by an alternative
method.
2
25fL
30
18
3
25fL
30
18
2
30
25fL18