Abbott AEROSET - Benzodiazepines; Cross Reactivity Testing Performed on the AEROSET System by SYVA

PROPRIETARY INFORMATION
CONFIDENTIAL MATERIAL
Assays/Reagents Not for Customer Distribution
112
AEROSET
®
System Troubleshooting Guide
94816-107—November 2004
Benzodiazepines
Cross Reactivity Testing Performed on the AEROSET System by SYVA
Compounds listed in the following table yielded a result
approximately equivalent to the Multi DOA Cutoff calibrator
(200 ng/mL lormetazepam).
Compounds listed in the following table yielded a negative
result at 200 ng/mL lormetazepam (Multi DOA Cutoff
calibrator) when tested at the concentration listed.
Compound
Concentration
Calculated ng/mL
SYVA Package Insert
ng/mL
7-aminoflunitrazepam 341 295
Compound
SYVA Package Insert
µg/mL (Tested at
150 ng/mL Cutoff)
Acetaminophen 1,000
N-Acetylprocainamide (NAPA) 400
Acetylsalicylic acid 1,000
Alpha-acetyl-N, N-dinormethadol
(dinor LAAM)
25
l-Alpha-acetylmethodol (LAAM) 25
Amitriptyline 1,000
Buprenorphine 100
Caffeine 1,000
Cimetidine 1,000
Clomipramine 2.5
Clonidine 1,000
Codeine 500
Cotinine 100
Cyclobenzaprine 28
Desipramine 800
Diphenhydramine 1,000
Doxepin 10
2-Ethylidene-1,5-dimethyl-3,
3-diphenylpyrrolidine (EDDP)
1,000