Agilent 8453 Dissolution Testing System Installing and Operating Manual 51
Setting Up 2
Installing a Valve-based Sampling System
Troubleshooting
Tab le 13 Troubleshooting Valve-based Sampling Systems
Problem Action
Invalid or unusual spectrum caused by sticky
bubbles in flow cell.
Sticky bubbles on the window of the flow cell
can be minimized by cleaning the tubing and
flow cell with a solution of 2% passivating and
cleaning fluid (part number 5062-8529).
Invalid or unusual spectrum caused by bubbles
in the flow cell moving up through the light path
during measurement.
Specify a longer cycle time (7.5 or 10 minutes) to
increase the pump and wait time.
Use flow cells with a wide aperture.
Cross contamination. Check the flow rate of the pump and replace the
pump tubing if necessary.
Specify a longer cycle time (7.5 or 10 minutes) to
increase the pump time.
Adjust the speed control of the peristaltic pump
to a higher speed.
Check tubing for possible flow restrictions.
Use a flow cell with a smaller inner volume.
Extensive bubbles in tubing. Check tubing for possible air leaks.
Check surfaces of the ferrules and exchange
ferrules which are scratched.
Tighten fittings and unions.
Check the fittings at the valve heads.
Change filter tips and/or use filter tips with a
wider pore size, if appropriate.
Leaking valve. Check your valve according to the procedure
given in Chapter 4, “Using the Valve Unit and
Valve-pump Controller”.
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