Roche Diagnostics
Instructions for Use · Version 10.0 103
9180 Electrolyte Analyzer 7 Measurement
Interference
Interference
The measuring module and measuring sensors were tested with respect to their
interference stability with the given chemical substances and pharmaceuticals.
Interferents can be a significant source of error in clinical analyses. While the
precision can be determined by internal QC and the correctness can be determined
by verifying reference samples, possible sources of interference cannot be identified
during ongoing operation. For this reason, the effect of potentially interfering
substances was determined.
u Interference Testing in Clinical Chemistry; Approved Guideline EP-7 Vol. 25; No. 27 of
the Clinical and Laboratory Standard Institutes (CLSI).
The results of the interference measurements have been divided into 3 categories:
1. Substances that do not impair precision and thus show no interference (see
Substances without effect (plasma samples) (p. 103) and Substances without effect
(whole blood samples) (p. 104)).
2. Substances that impair precision, but its deviation is within the limits of
correctness (see Effect of the substances (plasma samples) (p. 105) and Effect of the
substances (whole blood samples) (p. 106)), and
3. Substances that violate the specified limits of correctness and cause a significant
deviation in the measured value. The deviations as a function of the
concentrations are specified in Table C-4 and Table C-5.
Substances without effect
The following substances were tested, but show no effect on the measurement
parameters and thus do not violate the specifications.
Plasma samples
Substance Concentration Tested analyte
Acetoacetic acid (3-Oxobutyric acid) 2.000 mmol/L K, Na, Cl
Acetylcysteine 10.200 mmol/L Cl, Li
Ampicillin 0.152 mmol/L Cl, Li
Aspirin (Acetylsalicylic acid) 3.620 mmol/L Cl, Li
Calcium chloride 5.000 mmol/L Li
Cefoxitin 1.546 mmol/L Cl, Li
Chlorpromazine 0.0063 mmol/L Cl, Li
Doxycycline 0.0675 mmol/L Cl, Li
EDTA (Ethylenediaminetetraacetic acid) 0.0034 mmol/L Cl, Li
Hemoglobin 2.000 g/L Cl, Li
Ibuprofen 2.425 mmol/L Cl, Li
Isoniazid 0.292 mmol/L K, Ca, Na, Cl, Li
Lithium acetate 3.200 mmol/L K, Na, Cl
Magnesium acetate 15.000 mmol/L K, Cl, Li
Metronidazole 0.701 mmol/L K, Ca, Na, Cl, Li
Table 7-1 Substances without effect (plasma samples)
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