Waters TQ Detector User Manual

MS/MS operating modes 1-13
Multiple reaction monitoring mode
Typical application
You typically use MRM to quantify known analytes in complex samples:
• Drug metabolite and pharmacokinetic studies.
• Environmental, for example, pesticide and herbicide analysis.
• Forensic or toxicology, for example, screening for target drugs in sport.
MRM does not produce a spectrum because only one transition is monitored at
a time. As in SIR, a chromatogram is produced.
Constant neutral loss mode
Constant neutral loss mode detects the loss of a specific neutral fragment or
functional group from an unspecified precursor(s).
The scans of MS1 and MS2 are synchronized. When MS1 transmits a specific
precursor ion, MS2 “looks” to see whether that precursor loses a fragment of a
certain mass. If it does, the loss registers at the detector.
In constant neutral loss mode, the spectrum shows the masses of all
precursors that actually lost a fragment of a certain mass.
MS1
Static (at precursor mass)
MS2
Static (at product mass)
Collision cell
Pass all masses

Waters TQ Detector Specifications

General

Brand	Waters
Model	TQ Detector
Category	Measuring Instruments
Language	English