1-14 Waters TQ Detector
Constant neutral loss mode
Typical application
You typically use constant neutral loss mode to screen mixtures for a specific
class of compound that is characterized by a common fragmentation pathway,
indicating the presence of compounds containing a common functional group.
Sample inlet
Either of two methods delivers solvent and sample to the installed probe:
• An LC system, which delivers the eluent from an LC analysis.
• IntelliStart Fluidics system, which uses onboard solutions to automate
instrument optimization. You can deliver solutions by direct or
combined infusion.
Leak sensors
Where fitted, leak sensors in the drip trays of the ACQUITY UPLC system
and the TQ Detector continuously monitor system components for leaks. A
leak sensor stops system flow when its optical sensor detects about 1.5 mL of
accumulated, leaked liquid in its surrounding reservoir. At the same time, the
ACQUITY UPLC Console displays an error message alerting you that a leak
has developed.
Tip: If you are using MassLynx software, refer to the software release notes
provided at installation to confirm whether the leak sensors are enabled.
See Waters ACQUITY UPLC Leak Sensor maintenance instructions for
complete details.
MS1
Scanning
(synchronized with MS2)
Collision cell
Pass all masses
MS2
Scanning
(synchronized with MS1)