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TQ Detector
Waters TQ Detector User Manual
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2-1
2
Prep
aring for Operation
This chapter describes how to start and shut-down the instrument.
Content
s
T
opic
Page
Starting the instrument
2-2
Preparing the IntelliStart Fluidics system
2-7
Rebooting the instrument
2-12
Leaving the mass spectromete
r ready for oper
ation
2-14
34
36
Table of Contents
Default Chapter
2
Copyright Notice
2
Trademarks
2
Customer Comments
3
Safety Considerations
4
Considerations Specific to the TQ Detector
4
Operating this Instrument
7
Applicable Symbols
7
Intended Use
7
Calibrating
7
Quality Control
8
ISM Classification
9
EC Authorized Representative
9
Table of Contents
11
1 Waters TQ Detector
18
Overview
18
ACQUITY TQD UPLC/MS System
20
Software and Data System
21
ACQUITY UPLC Console
22
Ionization Techniques and Source Probes
23
Electrospray Ionization (ESI)
23
Combined ESI and APCI (Esci)
23
Atmospheric Pressure Chemical Ionization
24
Atmospheric Pressure Photoionization
24
Ion Optics
25
MS Operating Modes
26
MS/MS Operating Modes
27
Product (Daughter) Ion Mode
27
Precursor (Parent) Ion Mode
28
Multiple Reaction Monitoring Mode
28
Constant Neutral Loss Mode
29
Sample Inlet
30
Leak Sensors
30
Vacuum System
31
Rear Panel
31
Intellistart Fluidics System
33
Overview
33
System Operation
34
2 Preparing for Operation
36
Starting the Instrument
36
Configuring Intellistart
39
Verifying the Instrument's State of Readiness
39
Tuning and Calibration Information
39
Running the Instrument at High Flow Rates
40
Monitoring the Instrument Leds
40
Preparing the Intellistart Fluidics System
41
Installing the Solvent Manifold Drip Tray
41
Installing the Reservoir Bottles
42
Diverter Valve Positions
44
Purging the Infusion Syringe
46
Rebooting the Instrument
46
Rebooting the Instrument by Pressing the Reset Button
47
Leaving the Mass Spectrometer Ready for Operation
48
Emergency Instrument Shutdown
48
3 ESI and Esci Modes of Operation
50
Introduction
50
Installing the ESI Probe
50
Installing the Corona Pin
54
Optimizing the ESI Probe for Esci Operation
56
Removing the Corona Pin
56
Removing the ESI Probe
58
4 Optional APCI Mode of Operation
62
Atmospheric Pressure Chemical Ionization
62
Ionsabre APCI Probe
62
Installing the Ionsabre APCI Probe
63
Installing the Corona Pin
66
Removing the Corona Pin
66
Removing the Ionsabre APCI Probe
67
5 Maintenance Procedures
69
Maintenance Schedule
71
Spare Parts
73
Troubleshooting with Connections INSIGHT
73
Safety and Handling
74
Preparing the Instrument for Work Performed on the Source
75
Operating the Source Isolation Valve
76
Removing O-Rings and Seals
78
Cleaning the Instrument's Exterior
79
Emptying the Exhaust Trap Bottle
79
Emptying the Roughing Pump Exhaust Liquid Trap Bottle
81
Gas Ballasting the Roughing Pump
83
Gas Ballasting a Pump Fitted with a Screwdriver-Operated Gas Ballast Valve
84
Gas Ballasting a Pump Fitted with a Handle-Operated Gas Ballast Valve
85
Checking the Roughing Pump Oil Level
86
Adding Oil to the Roughing Pump
86
Cleaning the Source Components
88
Cleaning the Sample Cone and Gas Cone
88
Removing the Cone Gas Assembly from the Source
88
Disassembling the Cone Gas Assembly
91
Cleaning the Sample Cone and Gas Cone
92
Assembling the Cone Gas Assembly
95
Fitting the Cone Gas Assembly to the Source
96
Cleaning the Ion Block, Isolation Valve, and Extraction Cone
98
Removing the Ion Block Assembly from the Source Assembly
98
Disassembling the Source Ion Block Assembly
100
Cleaning the Ion Block, Isolation Valve, and Extraction Cone
108
Assembling the Source Ion Block Assembly
110
Fitting the Ion Block Assembly to the Source Assembly
113
Cleaning the Source Hexapole Assembly
115
Removing the Ion Block Assembly, Ion Block Support, and Hexapole from the Source Assembly
115
Cleaning the Hexapole Assembly
117
Fitting the Hexapole Assembly, PEEK Ion Block Support, and Ion Block Assembly to the Source Assembly
120
Replacing the ESI Probe Tip
122
Replacing the ESI Probe Sample Capillary
123
Cleaning the Ionsabre APCI Probe Tip
130
Replacing the Ionsabre APCI Probe Sample Capillary
130
Removing the Existing Capillary
130
Installing the New Capillary
135
Cleaning or Replacing the Corona Pin
139
Replacing the APCI Probe Heater
140
Replacing the Ion Block Source Heater
142
Replacing the Source Assembly Seals
147
Removing the Source Enclosure from the Instrument
147
Disassembling the Source Enclosure and Probe Adjuster Assembly
150
Removing the Seals from the Source Enclosure and Probe Adjuster Assembly
151
Fitting the New Source Enclosure and Probe Adjuster Assembly Seals
154
Assembling the Probe Adjuster Assembly and Source Enclosure
155
Fitting the Source Enclosure to the Instrument
156
Maintaining the Instrument Air Filters
158
Cleaning the Air Filter Inside the Instrument's Lower Bezel
158
Replacing the Air Filter Inside the Lower Bezel
159
Cleaning the Air Filter Behind the Source Probe
160
Fit the Probe to the Source
161
Replacing the Air Filter Behind the Source Probe
162
Replacing the Roughing Pump Oil
163
If You Are Fitting an ESI Probe, See "Installing the ESI Probe" on Page
163
If You Are Fitting an Ionsabre APCI Probe, See "Installing the Ionsabre APCI Probe" on Page
163
Start the Instrument (See "Starting the Instrument
165
Replacing the Roughing Pump's Oil Demister Element
166
A Safety Advisories
177
Warning Symbols
177
Task-Specific Hazard Warnings
177
Specific Warnings
178
Caution Symbol
180
Warnings that Apply to All Waters Instruments
180
Electrical and Handling Symbols
186
Electrical Symbols
186
Handling Symbols
187
B External Connections
189
External Wiring and Vacuum Connections
189
Connecting the Oil-Filled Roughing Pump
190
Making the Electrical Connections for a Roughing Pump with an External Relay Box
195
Making the Electrical Connections for a Roughing Pump Without an External Relay Box
196
Connecting the Oil-Free Roughing Pump
197
Making the Electrical Connections for an Oil-Free Roughing Pump
204
Connecting to the Nitrogen Gas Supply
205
Connecting to the Collision Cell Gas Supply
207
Connecting the Nitrogen Exhaust Line
207
Connecting the Liquid Waste Line
210
Connecting the Workstation
212
Connecting Ethernet Cables
213
I/O Signal Connectors
213
Signal Connections
215
Connecting to the Electricity Source
218
C Materials of Construction and Compliant Solvents
221
Preventing Contamination
221
Items Exposed to Solvent
221
Solvents Used to Prepare Mobile Phases
222
Assembling Required Materials
225
Preparing the Sulfadimethoxine Standard
225
Storing the Solutions
226
Using the Solution in an LC/MS System Check Run
226
500 D Preparing Samples, LC/MS System Check, Empower Software
225
Index
228
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Waters TQ Detector Specifications
General
Brand
Waters
Model
TQ Detector
Category
Measuring Instruments
Language
English
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