7.6.2 Perform System CIP
Introduction
The System CIP method is used to fill the instrument and the selected inlets and outlets
with cleaning solution.
WARNING
Hazardous substances. When using hazardous chemicals,
take all suitable protective measures, such as wearing pro-
tective clothing, glasses and gloves resistant to the sub-
stances used. Follow local and/or national regulations for
safe operation and maintenance of the product.
Hazardous chemicals during run. When using hazardous
chemicals, run System CIP and Column CIP to flush the
entire system tubing with distilled water, before service and
maintenance.
If hazardous chemicals are used for system or column cleaning, wash the
system or columns with a neutral solution in the last phase or step.
Tip:
Maintenance interval
Perform a System cleaning in place (System CIP) when required, for example between
runs where different samples and buffers are used. This is important to prevent cross-
contamination and bacterial growth in the instrument.
Required material
The following materials are required:
•
Appropriate cleaning solutions (e.g., 1 M NaOH, buffer solution or distilled water).
•
Syringe, 25 ml
ÄKTA avant User Manual 29035184 AE 289
7 Maintenance
7.6 Maintenance when required
7.6.2 Perform System CIP
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