411829-L, Maintenance April 2012 Page 5-7
5
5.10 Leaks
WARNING
Follow all generally-accepted lab safety procedures and applicable laws
and regulations.
Always follow local and national safety regulations and the solvent
manufacturer’s safety, handling, storage, and disposal recommendations;
see solvent manufacturer’s MSDS sheets.
Always follow the Principles of Good Laboratory Practice when handling
potentially hazardous substances.
The Isolera system operates using electricity, which can introduce
additional hazards with certain solvents if not properly connected, vented,
or set up with recommended manufacturer approved settings.
Personnel working with or near the Isolera system must wear protective
clothing, safety gear, and eye protection that have been approved by
applicable local and national safety regulations.
Use only tubing, nuts, and ferrules supplied by Biotage.
5.10.1 Shut Down the System
If a leakage is observed, shut down the system as follows:
1. If the Leak Detected dialog is open, close it by pressing Close.
2. If a purification is in progress, press Stop at the Status tab and then Abort in the Stop dialog.
3. If a prime is in progress, press End Prime at the Solvents tab.
4. If an air flush (started by the user) is in progress, press End Air Flush at the Solvents tab.
The Air Flush feature is not available with Isolera Prime.
5. If using an Isolera Four system, remove any queued purifications at the Status tab by pressing
Remove.
6. Press Main Menu in the right-hand panel.
7. Press Shut Down.
8. When the message It is now safe to turn off the system appears on the screen, turn off the
system. The power switch is located underneath the touch screen.
5.10.2 Internal Leakage
Internal leakage, due to e.g. worn pump seals or tube fittings, is drained through drain ports
underneath the system.
If an internal leakage is observed:
1. Shut down the system as described in section 5.10.1.
2. Disconnect the power cord from the power outlet.
3. Ensure that the leakage is not external; check all tubes and connections for leaks.
4. Contact Biotage 1-Point Support; see contact details on page 7-1.
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