9.5.2 Chemical resistance specifications
Introduction
This section provides detailed information about chemical resistance of the ÄKTA pure instrument to
some of the most commonly used chemicals in liquid chromatography. Regarding exposure to solutions
not covered by this information, contact your GE representative for recommendations.
A user can be exposed to large volumes of chemical substances over a long time period. Ma-
terial Safety Data Sheets (MSDS) provide the user with information regarding characteristics,
human and environmental risks and preventive measures. Make sure that you have the MSDS
available from your chemical distributor and/or databases on the internet.
Note:
Aqueous buffers
The specified aqueous buffers are suitable for continuous use.
CAS no/EC noConcentrationChemical
N/AN/AAqueous buffers
pH 2-12
Strong chemicals and salts for CIP
The following chemicals are suitable for up to 2 h contact time at room temperature.
CAS no/EC noConcentrationChemical
75-05-8/ 200-835-270%Acetic acid
N/A10%Decon 90
75-08-1/ 200-837-3100%Ethanol
67-56-1/ 200-659-6100%Methanol
7647-01-0/ 231-595-70.1 MHydrochloric acid
1
67-63-0/ 200-661-7100%Isopropanol
1310-73-2/ 215-185-52 MSodium hydroxide
N/A1 M/40%Sodium hydroxide/ethanol
7647-14-5/ 231-598-34 MSodium chloride
7681-52-9/231-668-310%Sodium hypochlorite
1
If hydrochloric acid, HCl, is used as a cleaning agent when columns are connected to the system, the HCl concen-
tration should not exceed 0.1 M in the pressure sensors. Remember that the ÄKTA pure system has pressure sensors
in the column valve V9-C.
For other parts of the system up to 1 M HCl is acceptable for short periods of use. See Cleaning chemicals, on page432
ÄKTA pure User Manual 29119969 AB 433
9 Reference information
9.5 Chemical resistance guide
9.5.2 Chemical resistance specifications
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