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2727.5 Semiannual maintenance ...............................................................................................................................................

2737.5.1 Clean the UV flow cell ........................................................................................................................................................................................

2757.5.2 Replace the pH electrode .................................................................................................................................................................................

2767.6 Maintenance when required ..........................................................................................................................................

2777.6.1 Clean the instrument externally ...................................................................................................................................................................

2787.6.2 Perform System CIP ...........................................................................................................................................................................................

2847.6.3 Perform Column CIP ..........................................................................................................................................................................................

2887.6.4 Clean Fraction collector F9-C .........................................................................................................................................................................

2907.6.5 Clean Fraction collector F9-R .........................................................................................................................................................................

2917.6.6 Storage of the pH electrode ...........................................................................................................................................................................

2937.6.7 Clean the pH electrode .....................................................................................................................................................................................

2967.6.8 Clean the pump head check valves ............................................................................................................................................................

2997.6.9 Wipe off excess oil from the pump head ..................................................................................................................................................

3007.6.10 Clean the Conductivity flow cell ....................................................................................................................................................................

3027.7 Calibration procedures .....................................................................................................................................................

3037.7.1 Calibrate the pH monitor .................................................................................................................................................................................

3057.7.2 Calibrate the pressure monitors ...................................................................................................................................................................

3087.7.3 Calibrate the Conductivity monitor .............................................................................................................................................................

3127.7.4 Calibrate the UV monitors ...............................................................................................................................................................................

3167.8 Replacement procedures ................................................................................................................................................

3177.8.1 Replace tubing and connectors ....................................................................................................................................................................

3197.8.2 Replace internal tubing in Fraction collector F9-C ...............................................................................................................................

3227.8.3 Replace the Mixer ................................................................................................................................................................................................

3237.8.4 Replace the O-ring inside the Mixer ............................................................................................................................................................

3257.8.5 Replace the UV monitor U9-M flow cell .....................................................................................................................................................

3287.8.6 Replace the UV monitor U9-L flow cell ......................................................................................................................................................

3307.8.7 Replace Flow restrictor .....................................................................................................................................................................................

3317.8.8 Replace the inlet filters .....................................................................................................................................................................................

3327.8.9 Replace the pump head check valves ........................................................................................................................................................

3357.8.10 Replace pump piston seals of Pump P9 or P9H ....................................................................................................................................

3447.8.11 Replace pump piston seals of Pump P9-S ...............................................................................................................................................

3517.8.12 Replace pump pistons ......................................................................................................................................................................................

3527.8.13 Replace pump rinsing system tubing .........................................................................................................................................................

3558 Troubleshooting ...............................................................................................................................................

3568.1 Introduction to troubleshooting ...................................................................................................................................

3588.2 Troubleshooting: General Checklist ............................................................................................................................

3608.3 Troubleshooting: Monitors ..............................................................................................................................................

3758.4 Troubleshooting: Valves ...................................................................................................................................................

3778.5 Troubleshooting: Fraction collector ............................................................................................................................

3878.6 Troubleshooting: Pumps ..................................................................................................................................................

3948.7 Troubleshooting: Other components .........................................................................................................................

4018.8 Troubleshooting: Instrument communication .......................................................................................................

4038.9 Troubleshooting: Method development ...................................................................................................................

4048.10 Error codes .............................................................................................................................................................................

4109 Reference information ....................................................................................................................................

4119.1 System specifications ........................................................................................................................................................

4139.2 Module specifications .......................................................................................................................................................

4209.3 Tubing and connectors .....................................................................................................................................................

4289.4 Recommended tubing kits for prepacked columns ............................................................................................

4319.5 Chemical resistance guide ..............................................................................................................................................

4329.5.1 General information about biocompatibility and chemical resistance .......................................................................................

4339.5.2 Chemical resistance specifications .............................................................................................................................................................

4369.6 Wetted materials .................................................................................................................................................................

ÄKTA pure User Manual 29119969 AB 5

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