H50/H51 Hematology Analyzer User Manual Measurement Principle
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2) PLCR (Platelet Large Cell Ratio) indicates the percentage of large platelets with a
volume >12 fL. Aside from the two flexible discriminators which delimit the volume
distribution curve, there is additionally a fixed discriminator at 12 fL (marked in red on
below picture). The PLCR is the percentage of cells higher than 12fL regarding the whole
platelets count.
PLCR is significantly decreased in patients with thrombocytosis while it is increased in
thrombocytopenia. In patients with high counts, PLCR is significantly decreased in reactive
thrombocytosis than neoplastic thrombocytosis. PLCR is more likely higher in destructive
thrombocytopenia than hypo-proliferative thrombocytopenia. PLCR is inversely related to
platelet count and directly related to PDW and MPV.
3) Large platelets cell count (PLCC) is made from PLCR and PLT by formula below:
PLCC = PLCR x PLT
Where PLCC is expressed in 10
9
/L, PLCR is expressed in % and PLT is expressed in 10
9
/L.
4) PDW means the size distribution spread of the platelets population derived from the PLT
histogram.
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