Function and setup multi N/C 2100S
32
The CO
2
or NO concentration is detected several times every second. An integer over
time is calculated from this signal sequence. The integer is proportional to the
concentration of the carbon or nitrogen in the measurement solution. Afterwards, the
calculation of the carbon or nitrogen content in the sample is performed via a previously
determined calibration function.
3.3 Measuring method
The analyzer multi N/C 2100S pharma is used to determine the TN
b
parameter in
pharmaceutical samples.
The analyzer multi N/C 2100S is used to determine the following parameters as sum
parameters.
TC - Total Carbon
TOC - Total Organic Carbon
TIC - Total Inorganic Carbon
NPOC - Non Purgeable Organic Carbon
NPOC+ - Non Purgeable Organic Carbon, determined via differential measurement
DOC - dissolved organic carbon (corresponds to TOC after sample filtration through
0.45 µm filter) (Dissolved Organic Carbon)
TN
b
- total bound nitrogen (total nitrogen)
In the control and analysis software multiWin the detection of several parameters can
be combined.
3.3.1 TC analysis
During the TC analysis the total carbon contained in the sample, i.e. organic and
inorganic bound carbon as well as elemental carbon is detected.
The sample is metered via a microliter syringe into the combustion tube, digested and
the generated carbon dioxide is detected.
Parallel to the TC detection the TN
b
detection is possible.
3.3.2 TOC analysis
During the TOC analysis the total organic carbon content of a sample is detected.
The TOC determination in the analyzer is performed according to the differential
method, which can be described with the following equation (4).
TOC = TC – TIC (4)
TOC … total organic carbon
TC … total carbon
TIC … total inorganic carbon
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