112 BioPAT
®
Trace | Multi Trace Operating Instructions
Operation
8.5.4 Avoiding Contaminations in the Tubing Set
During longer processes (over a period of weeks), biofilm can form inside the
tubing set over time. This can result in the lines clogging or in highly
fluctuating measured values.
This applies in particular to storage tanks with ready-for-use diluted transport
solution that are repeatedly refilled with fresh solution. It is advantageous to
completely replace the almost-empty container with a new container with
fresh solution to avoid a transfer of microbes.
The rinsing line of the conductivity cell when removing air bubbles in the
measuring chamber presents another opportunity for microbes to intrude
into the tubing set. Therefore, it is imperative to use only fresh solutions and|
or a sterile filter attachment for this purpose.
In some long-term cultivations, it was observed that biofilm would form in the
waste line and spread into the drip chamber. In this case, it is also
recommendable to regularly replace the waste containers and to prevent the
waste line from being immersed in the waste. The waste containers can be
further protected by adding cleaning solution (see Chapter
“3.6 Consumables”, page 21).
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