Operator’s Manual – OPTI CCA-TS Ca-3
Linearity
4
Wherever possible, linearity for the OPTI CCA measurement has been established against reference
materials or methods. Ionized calcium linearity is established by measurement of gravimetrically
prepared, N.I.S.T. traceable aqueous standard solutions (ionized calcium
ST
) and by measurement of
N.I.S.T. Standard Reference Material 956a Electrolytes in Human Serum (ionized calcium
NIST
)
Correlation
Slope Intercept Coefcient Sy.x Range n
ionized Calcium
ST
1.0022 -0.0025 0.99983 0.017 0.2 - 3.0 24
ionized Calcium
NIST
0.9938 0.0081 0.99843 0.016 1.07 - 1.71 12
Correlation to Other Methods
4
OPTICCA-TSvsotherpH/BloodGasInstrumentsonwholebloodinatypicalsetting
Excess blood aliquots from specimens collected for blood gas analyses were analyzed by both traditional
and non-traditional operators of blood gas equipment in hospital laboratories. The blood was analyzed on
the OPTI CCA after obtaining the requisite results from existing instrumentation used for these analyses
and operated and controlled following their established procedures.
Correlation
ComparativeMethod* Slope Intercept Coefcient Sy.x Range n
Analyzer A (whole blood) 0.8732 0.064 0.8392 0.07 0.68 - 1.34 103
Analyzer B (whole blood) 0.9548 -0.024 0.9453 0.04 0.94 - 1.67 101
* For more information on specic analyzers used, please contact OPTI Medical Technical Support.
References
1. Tietz, Norbert W., Ed., Clinical Guide to Laboratory Tests, 2nd Ed., (Philadelphia: W.B.Saunders,
Co., 1990) p. 436
.
2. Burritt MF, Pierides AM, Offord KP: Comparative studies of total and ionized serum calcium values
in normal subjects and in patients with renal disorders. Mayo Clinic proc. 55:606, 1980.
3. Tsien R, New Calcium Indicators and Buffers with High Selectivity Against Magnesium and Protons,
Biochemistry 19, p.2396-2404, 1980
.
4. OPTI Medical. Model equation for regression statistics is: [results of OPTI Analyzer] = slope(m)
[comparative method results] + intercept(b).
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