Clinical Guide
Smart532
™
A-2 UM-1151440EN, Rev. C, May 2016
Tissue effects include, in incremental order: expression of heat shock
proteins
1
, denaturation of proteins, photocoagulation, vaporization and
ablation
2
. For Smart532, the effect of interest is photocoagulation.
Analysis of clinical and laboratory experience indicates that irradiance of ~
100-500 W/cm
2
, corresponding to heating the tissue by ~12-25°C above
body temperature, is required for photocoagulation of tissues
2,3
.
Warning
● Lumenis and/or related entities assume no responsibility for
parameters, techniques, methods or results. Physicians must
use their own clinical judgment and professionalism in
determining all aspects of treatment, i.e. technique, proper
power settings, intervals, durations, etc.
● Physicians should seek formal training from established
courses on the use of the laser and its accessories. Any
information given in this text is not intended to provide such
instructions, and is not to be considered a substitute.
Caution
● The laser unit should be handled carefully. Maintenance and
service should be performed only by Lumenis trained
personnel.
● In using any delivery devices or accessories, attention must
be paid to the specific instructions and precautions applicable
to those devices. This manual and the appropriate delivery
device operator manual should be carefully read and
comprehended before use.
Warning
Complications of laser therapy are the same as complications for
any other surgical procedure. Some of these complications may be
serious and could result in death or permanent blindness.
1
C. Sramek, M. Mackanos, R. Spitler, L. Leung, H. Nomoto, C. Contag and D.
Palanker, "Non-damaging retinal phototherapy: dynamic range of heat shock
protein expression". Invest. Opthalmol. Vis. Sci., vol. 52, no. 3, pp. 1780-7, 2011.
2
G. Kulkarni, "Laser-tissue interaction studies for medicine," Bull Materials Sci,
vol. 11, pp. 239-44, 1988.
3
J. Krauss and C. Puliafito, "Lasers in ophthalmology," Lasers Surg Med, vol. 17,
no. 2, pp. 102-59, 1995.
and Precautions
(AEs)
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