ThinPrep™ 5000 Processor with AutoLoader Operator’s Manual
3.3
PRESERVCYT™ & CYTOLYT™ SOLUTIONS
Handling/Disposal
Handle all chemical-containing materials carefully in accordance with safe laboratory practices.
When required by reagent composition, additional precautions are marked on the reagent containers
or in the instructions for use.
Dispose of PreservCyt
™
Solution according to the guidelines for disposing of hazardous waste.
PreservCyt Solution contains methanol.
PreservCyt Solution was challenged with a variety of microbial and viral organisms. The following
table presents the starting concentrations of viable organisms and the log reduction of viable
organisms found after 15 minutes in the PreservCyt Solution. As with all laboratory procedures,
universal precautions should be followed.
Organism Initial Concentration
Log Reduction After
15 Minutes
Candida albicans
5.5 x 10
5
CFU/ml
≥4.7
Candida auris
2.6 x 10
5
CFU/ml
≥5.4
Aspergillus niger
4.8 x 10
5
CFU/ml
2.7*
Escherichia coli
2.8 x 10
5
CFU/ml
≥4.4
Staphylococcus aureus
2.3 x 10
5
CFU/ml
≥4.4
Pseudomonas aeruginosa
2.5 x 10
5
CFU/ml
≥4.4
Mycobacterium tuberculosis
†
9.4 x 10
5
CFU/ml
4.9**
Rabbitpox virus
6.0 x 10
6
PFU/ml
5.5***
HIV-1
3.2 x 10
7
TCID
50
/ml
≥7.0***
Hepatitis B virus
†
2.2 x 10
6
TCID
50
/ml
≥4.25
SARS-CoV-2 virus
1.8 x 10
6
TCID
50
/ml
≥3.75
* After 1 hour 4.7 log reduction
** After 1 hour 5.7 log reduction
*** Data is for 5 minutes
† Organisms were tested with similar organisms from the same genus to assess
antimicrobial effectiveness
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