Name: Thermo Scientific TSQ Quantis
Brand: Thermo Scientific
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Introduction

MS Mass-To-Charge Ratio Ranges

Thermo Scientific TSQ Altis, Quantis, and Fortis Hardware Manual 3

MS Mass-To-Charge Ratio Ranges

The TSQ Altis, TSQ Quantis, and TSQ Fortis MSs detect different ranges of mass-to-charge

ratios.

Instrument m/z Range in amu

TSQ Altis 5–2000

TSQ Quantis 5–3000

TSQ Fortis 5–3000

Default Chapter7
- Default Chapter7
  - Table of Contents7
- Preface15
Chapter 1 Introduction19
- Mass Spectrometry Models19
- MS Mass-To-Charge Ratio Ranges21
- Principles of Operation23
  - Overview of the MS System23
  - Figure 1. Block Diagram of MS Hardware Components23
Chapter 2 Principles of Operation23
- Overview of Ion Optics and Mass Analyzer25
- Figure 2. Ion Optics and Mass Analyzer Assemblies25
Chapter 3 Vacuum System27
- Vacuum Pumps27
- Vacuum Manifold28
- Figure 3. Placement of the Turbomolecular Pump Next to the Vacuum Manifold28
- Vacuum System Block Diagram30
- Figure 4. Functional Block Diagram of the Altis Vacuum System30
- Vacuum Gauges31
Chapter 4 Internal Gas Supply33
- Figure 5. Gas Inlets and Vacuum (Foreline) Port (Left Side of the MS)34
Chapter 5 Atmospheric Source Interface35
- API Source Interface Overview36
- Figure 6. API Source Interface for the TSQ Altis MS (Cross Section)36
- Ion Transfer Tube37
- Figure 7. Altis Ion Transfer Tube37
- Figure 8. Quantis Ion Transfer Tube37
- Figure 9. Fortis Ion Transfer Tube37
- RF and Exit Lens38
- Figure 10. Altis RF Lens and Exit Lens38
- Figure 11. Quantis RF Lens38
- Figure 12. Fortis Exit Lens39
Chapter 6 Ion Optics and Detector Components41
- MP00 Ion Optics41
- Figure 13. MP00 Lens (Left) and Lens L0 (Right)41
- MP0 Ion Optics and Beam Blocker42
- Dual-Mode, Discrete-Dynode Ion Detection System42
- Figure 14. MP0 Multipole with Neutral Beam Blocker (1)42
- Figure 15. EL11 (Left) and EL12 (Right) Lenses42
Chapter 7 Controls and Indicators43
- Leds43
- Figure 16. Leds on the Instrument Front Panel43
- Power Entry Module44
- Communications Panel45
- Figure 18. Communication Connectors (Right Side of the MS)46
- Cooling Fans48
Chapter 8 Using the MS Power Options49
- Turning the MS on49
- Placing the MS in Standby Mode49
- Shutting down the MS System in an Emergency50
- Figure 19. Main Power Switch on the Power Module50
Chapter 9 Shutting the MS System down Completely51
- Shutting the MS down Completely51
- Turning off the LC, Gases, Data System, and Autosampler52
- Figure 20. Electronic Service Switch and Main Power Switch52
Chapter 10 Restarting the MS System after a Shutdown53
- Restarting the Data System53
  - Restarting the Data System Using Windows53
  - Restarting the Data System Using the Power Button53
- Resetting the Mass Spectrometer54
- Figure 21. Reset Button (1) on the Communication Panel54
- Pumping the MS down55
- Figure 22. Electronic Service Switch and Main Power Switch55
- Resetting Calibration Parameters56
- Starting the LC, Gases, and Autosampler57
Chapter 11 MS Components On/Off Status59
Chapter 12 Maintaining the MS on a Daily Basis61
- Before Operating the Mass Spectrometer61
- After Operating the Mass Spectrometer65
Chapter 13 Recommended Inlet and Flow Rates67
- Guidelines for LC/H-ESI/MS Parameters67
- Guidelines for LC/APCI/MS Parameters67
- Guidelines for LC/NSI/MS Parameters68
Chapter 14 Connecting the Sample Flow to the Source69
- Connecting the Sample Flow to the H-ESI Source69
- Connecting the Sample Flow to the APCI Source70
- Figure 23. Connection to the H-ESI or the Low-Flow H-ESI Source70
- Figure 24. Connection to the APCI Spray Insert71
- Calibrating the MS73
  - Preparing the Syringe Pump for Calibration73
Chapter 15 Calibrating the MS73
- Preparing the MS for Calibration74
- Determining the Initial API Source Settings75
- Figure 25. Syringe Pump Settings Box75
- Evaluating the Spray Stability76
- Figure 26. Define Scan Parameters76
- Figure 27. Plot Chromatogram Dialog Box77
- Calibration Parameters78
- Calibrating and Tuning the MS78
Chapter 16 Optimizing the Compound Signal85
- Performing Compound Optimization Animation85
- Setting up for Compound Optimization85
- Optimizing Parameters in the Optimization Pane86
- Figure 34. Optimizing the Source Parameters in the Optimization Pane87
- Figure 35. Example Optimization of the RF Lens (SRIG RF) Tuning for M/Z 997.5588
- Figure 36. Examples of the Optimization Results Tables88
Chapter 17 Scan Types89
- Quadrupole Capacities90
- Summary of Scan Types90
- Full Scan Q1 and Q3 Scan Types91
- Selected Ion Monitoring Scan Type91
- Product Scan Type92
- Figure 37. Illustration of Product Scan Type92
- Precursor Scan Type93
- Neutral Loss Scan Type93
- Figure 38. Illustration of the Precursor Scan Type93
- Figure 39. Illustration of the Neutral Loss Scan Type94
- Selected Reaction Monitoring Scan Type95
- Figure 40. Examples of Compounds with a Common Fragment95
Chapter 18 Data Types97
- Profile and Centroid Data97
- Figure 41. Examples of Profile (Left) and Centroid (Right) Data97
- Ion Polarity Modes98
Chapter 19 Acquiring Sample Data99
- Creating an SRM Method Animation99
- Using Tune to Acquire Sample Data100
- Figure 42. Data Acquisition Pane in the Tune Window101
- Using the Xcalibur Data System to Acquire Sample Data102
- Using Templates in Thermo Xcalibur Instrument Setup104
- Figure 45. Templates in Method Editor104
Chapter 20 Maintenance Schedule and Supplies105
- MS Parts105
- Maintenance Schedule106
- Guidelines107
- Tools and Supplies107
Chapter 21 Maintaining the API Source and Replacing the H-ESI Needle111
- Cleaning the API Source Housing111
- Replacing the H-ESI Needle111
Chapter 22 Maintaining the RF Lens, Exit Lens, MP00 RF Lens, and Lens L0113
- Removing the API Source Interface113
- Figure 46. API Source Interface Removed from the Vacuum Manifold114
- Removing the RF Lens, Exit Lens, MP00 RF Lens, and Lens L0 (Altis/Quantis)115
- Figure 47. Removing the Multipole MP00 and Lens L0 Assembly (TSQ Altis MS)115
- Figure 48. Removing the RF Lens and Exit Lens (TSQ Quantis MS)116
- Figure 49. Removing the Lens L0 and Multipole MP00 from the MP00-L0 Mount Cage116
- Removing the Exit Lens, MP00, and Lens L0 (Fortis)117
- Figure 50. Removing the Multipole MP00 and Lens L0 Assembly (TSQ Fortis)117
- Cleaning the RF Lens, Exit Lens, MP00, and Lens L0118
- Figure 51. Removing the Exit Lens (TSQ Fortis)118
- Figure 52. Removing the Lens L0 and Multipole MP00 from the MP00-L0 Mount Cage118
- Reinstalling the API Source Interface119
Chapter 23 Maintaining the API Source Interface121
- Performing Source Maintenance Animation121
- Removing the Ion Sweep Cone and the Ion Transfer Tube122
- Figure 53. Ion Sweep Cone Removed from the MS Mount Assembly122
- Figure 54. Ion Transfer Tube Removal Tool (TSQ Altis MS)123
- Figure 55. Ion Transfer Tube Removal Tool (TSQ Quantis MS)124
- Figure 56. Ion Transfer Tube Removal Tool (TSQ Fortis MS)124
- Cleaning the Spray Cone and O-Ring125
- Figure 57. Spray Cone, O-Ring, Ion Transfer Tube, and Ion Sweep Cone125
- Cleaning the Ion Transfer Tube126
- Cleaning the Ion Sweep Cone126
Chapter 24 Maintaining the Forepumps and the Air Filter129
- Maintaining the Forepumps129
- Maintaining the Air Filter129
- Figure 58. Air Filter Location in the MS with the Front Cover Removed130
Appendix A Using Basic Tune Functions131
- Performing Compound Optimization Animation131
- Opening the Tune Window132
- Figure 59. Tune Window Showing the Define Scan Pane132
- Setting the Instrument System Controls133
- Setting the Instrument Power Mode134
- Checking the Instrument Readback Status135
- Setting the Tune Preferences136
- Figure 60. Tune Preferences Dialog Box136
- Using the Mass List Table in the Define Scan Pane137
- Using the History Pane139
- Using the Favorites Pane to Save System Settings139
- Figure 62. Favorites Pane140
- Figure 63. State Name Box140
Appendix B Setting up the Syringe with the Syringe Pump143
- Connecting the Syringe Union to the Syringe143
- Figure 64. PEEK Tubing Connection to Syringe Union143
- Setting up the Syringe Pump144
- Figure 65. Syringe Pump with Syringe145
Appendix C Divert/Inject Valve147
- About the Divert/Inject Valve147
- Divert/Inject Valve Configurations148
- Divert/Inject Valve Controls149
- Figure 67. Divert/Inject Valve Plumbed as a Divert Valve149
- Figure 68. Divert/Inject Valve (Front View)150
Appendix D Setting up Sample Introduction Techniques151
- Setting up H-ESI or Low Flow H-ESI Direct Infusion151
- Setting up High-Flow Infusion Without an Autosampler155
- Setting up Loop Injections for Flow-Injection Analysis156
- Figure 71. HPLC Infusion Tee Valve156
- Setting up Injections Using the Autosampler157
- Figure 72. Injector Valve Set up157
- Figure 73. Divert/Inject Valve Plumbed as a Divert Valve158
Appendix E Replaceable Parts159
- Chemical Kit159
- Calibration Kit160
- MS Setup Kit161
- Performance Specification Kit161
- Single Mechanical Pump Kit162
- Dual Mechanical Pumps Kit162
- TSQ Source Installation Kit163
- API Source Interface163
- Miscellaneous Parts163
- Glossary165
- Index173

Thermo Scientific TSQ Quantis User Manual

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Brand	Thermo Scientific
Model	TSQ Quantis
Category	Laboratory Equipment
Language	English