Agilent 6500 Series Q-TOF LC/MS Maintenance Guide 53
Maintenance 2
To clean the electrospray spray chamber weekly
To clean the electrospray spray chamber weekly
When required Weekly or whenever symptoms indicate that contamination exists in the spray
chamber and normal daily cleaning does not correct the problem.
Tools required • Abrasive paper, 4000 grit (p/n 8660-0827)
• Cloths, clean, lint-free (p/n 05980-60051)
• Cotton swabs (p/n 5080-5400)
• Gloves, clean
• Isopropanol, reagent grade or better
• Mobile phase, current
• Wash bottle, clean
• Water, reagent-grade or better
Parts required None
1 Turn off the spray chamber.
2 Remove the electrospray nebulizer.
3 Open the spray chamber and remove it from the instrument.
4 Fill the spray chamber with clean mobile phase, or with a mixture of
isopropanol and water.
Recent residue should be soluble in the mobile phase. If you are not sure what mobile
phase was used recently, a mixture of 50% isopropanol and 50% water works well as a
general cleaning solution.
The electrospray spray chamber operates at high temperatures. Allow sufficient
time to cool down before cleaning.
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