50 Agilent 6500 Series Q-TOF LC/MS Maintenance Guide
2Maintenance
To clean the electrospray spray chamber daily
To clean the electrospray spray chamber daily
When required Daily or at the end of each shift or anytime you suspect carryover
contamination from one sample or analysis to another.
Tools required • Cloths, clean, lint-free (p/n 05980-60051)
• Gloves, clean
• Isopropanol, reagent grade or better
• Mobile phase, current
• Wash bottle, clean
• Water, reagent-grade or better
Parts required None
1 Prepare the mobile phase you have been using.
2 Turn off the spray chamber.
3 Remove the electrospray nebulizer.
4 Open the spray chamber (Figure 6).
Recent residue should be soluble in the mobile phase. If you are not sure what mobile
phase was used recently, a mixture of 50% isopropanol and 50% water works well as a
general cleaning solution.
The electrospray spray chamber operates at high temperatures. Allow sufficient
time to cool down before cleaning.
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