Agilent 6500 Series Q-TOF LC/MS Maintenance Guide 69
Maintenance 2
ESI with Agilent Jet Stream Technology
ESI with Agilent Jet Stream Technology
This section describes the removal, disassembly, cleaning, and reassembly of
the electrospray interface with Agilent Jet Stream Technology.
To flush the nebulizer daily
When required Daily or at the end of each shift (or more often) to flush traces of samples and
buffers out of the tubing, valves and nebulizer
Tools required • Acetonitrile, HPLC-grade or better
• Water, HPLC-grade or better
Parts required None
1 Make sure acetonitrile and water are two of the solvents installed in your
liquid chromatograph.
2 Set the liquid chromatograph to pump a mixture of 90% acetonitrile and
10% water at 2 ml/minute.
3 Pump this mixture through the nebulizer for 3 minutes.
This is a good general-purpose flushing mixture but you may need to adjust it based on the
solvents, samples and buffers you are using. For example, a mixture of 50% acetonitrile and
50% water works well for removing salts.
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