Agilent 6500 Series Q-TOF LC/MS Maintenance Guide 93
Maintenance 2
To replace the APCI nebulizer needle
Figure 37 Corroded needle in nebulizer
3 Loosen the locknut next to the zero-dead-volume (ZDV) union. 
4 Remove the union from the nebulizer. 
5 Loosen the locknut of the needle holder. 
6 Unscrew the needle holder and pull it out of the nebulizer. 
7 Slide the non-tapered end of the needle through the new needle holder from 
the narrower side.
Figure 38 Sliding the non-tapered end of the needle through the new needle holder
8 Push a new ferrule, flat-side first, onto the needle. 
9 Be sure the needle does not extend from the ferrule. 
10 Reinstall the locknut and the union. Hand tighten the union.