Agilent 6500 Series Q-TOF LC/MS Maintenance Guide 103
Maintenance 2
To clean the multimode source daily
5 Rinse the interior of the spray chamber using the wash bottle filled with the
current mobile phase or with a mixture of isopropanol and water.
6 Wipe the interior of the spray chamber with a clean, lint-free cloth.
7 Rinse the area around the spray shield. Do not spray directly toward the tip
of the capillary. This can cause pressure surges in the vacuum system.
8 Dampen a clean cloth with the mobile phase. Wipe the spray shield, field
shaping electrodes and the area around the spray shield.
9 Replace the nebulizer and the APCI corona needle.
10 Install the thermocouple probe and adjust it so that it protrudes 15 mm
from the inner spray chamber wall.
11 Replace the cosmetic cover.
12 Close the spray chamber.
Recent residue should be soluble in the mobile phase. If you are not sure what mobile
phase was used recently, a solution of 50% isopropanol and 50% water works well as a
general cleaning solution.
Some mobile phases are dangerous. Use the degree of caution appropriate for the
mobile phase being used.
Sharp edges can be found inside the spray chamber, such as the separator. Pay
close attention when wiping the interior of the spray chamber.
Use the weekly cleaning process if symptoms of contamination persist, or if the spray
shield or capillary cap show significant discoloration that can not be removed by the normal
daily cleaning procedure.