CEM liberty - Page 86

Liberty
™
Automated Microwave Peptide Synthesizer
600178 • Revision 5 • October 2009
84
Microwave Options•
DeltaT Available in• Microwave Editor: When this option is enabled, the
delta T value can be changed when programming a microwave method in the
Microwave Editor.
Cooling Available in • Microwave Editor: When this option is enabled,
air cooling can be enable when programming a microwave method in the
Microwave Editor.
System Options•
Pause When Running on Battery Power: • When this option is enabled,
PepDriver will pause the current method in the event the laptop computer
switches to battery power. This is critical in the event of power failure. This
option is enabled by default.
Test System Visible:• When this option is enabled, the Test System button
is visible on the Cleaning Tab of the Maintenance Screen. This option is
enabled by default.
Vent Rotary 3 Valve on Start:• When this option is enabled, pressure to
Rotary 3 will be vented before starting the rst method in the queue. This
option is disabled by default.
Omit Check for • 125 mL Reaction Vessel: By default, if a method of 0.5
mmol scale or higher is loaded into the queue, PepDriver will prompt the user
to check that the correct reaction vessel is installed.
NOTE
During a microwave method, microwave power will only be applied until the
temperature reaches the programmed temperature. At that point, the power
will be turned off until the temperature drops to below the delta temperature
value. This reduces the risk of overshooting the temperature and improves
the quality of the synthesis. The default value for delta T is 5 degrees.
NOTE
During a microwave method, if air cooling is enabled, and the air cooling line
is connected to the Discover and to a nitrogen source, a stream of air will
be blown over the reaction vessel. This will decrease the time needed for
the temperature to drop below the delta T and for the microwave power to
resume. Air cooling is not recommended for peptide synthesis.
CAUTION
The 125 mL reaction vessel must be used for syntheses above 0.25 mmol.
Using the 35 mL reaction vessel for large syntheses will result in overlling
of the vessel, loss of product, and possible damage to the instrument.