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Parameter Specimen
Occurrence
Possible Indication of Error on MYTHIC 22
action
MCH
RBC count
The MCH is determined according to Hgb value and
RBC count. The limitations listed for Hgb and RBC
may cause indirect interferences.
MCHC
See Hgb and HCT
values interferences
The MCMH is determined according to Hgb and
HCT values. The limitations listed for Hgb and HCT
may cause indirect interferences.
RDWC
See RBC count
interferences
(?)
The RDWC is determined according to RBC count.
The limitations listed for RBC may cause
PLT
Platelet Aggregation
(-)
Cause:
Clumped platelets may cause a decreased
platelet count.
Indication:
aggregates may be detected on the
WBC scattergram with N1 &/or N2 &/or L1 &/or HL
flags, ↓Plt ↑MPV.
aggregates on smear.
The specimen should be
recollected in sodium
citrate anticoagulant and
Severe Microcytosis
(+)
Cause:
in case of severe microcytosis, microcytes
and schizocytes
are below the RBC inferior
threshold and may be counted with Platelets and
cause an erroneously high Plt count.
↓
↑
Plt R1 &/or P3 &/or P2 flags.
Seek for microcytes on
smear.
Megalocytic
Platelets
(-)
Cause :
may cause a low inaccurate platelet count as
these platelets exceed the upper threshold for the
platelet parameter and are not counted.
↓
↑
Seek for megalocytic
platelets on smear.
RBC agglutination (?)
Cause:
agglutinated RBC may trap platelets and
cause a low inaccurate Plt count.
Indication:
abnormal MCH and MCHC values.
Seek for clumped RBC on
smear.
Hemolysis (+)
Cause:
hemolyzed samples contain RBC stromas that
cause a high inaccurate Plt count.
Indication:
abnormal MCH and MCHC values
↓
(+): Instrument count is affected by an increase in the result.
(-): Instrument count is affected by a decrease in the result.
(?): Instrument count is affected by either an increase or decrease in the result which is sample dependent.