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4.4 ANALYTICAL LIMITATIONS
4.4.1 Recommendations
MAINTENANCE:
Please respect the maintenance procedures (9.1), calibration procedure (7) and the quality control procedure
(6) .Otherwise, results can be affected.
GENERALITIES:
Some abnormal samples may give incorrect results by automated cell counting methods. The following table
shows examples of specific specimens that could cause errors.
Each result for a new patient out of lab linearity limits or with an alarm must be checked
with a conventional method or checked with blood smear.
4.4.2 Interferences
Parameter Specimen
Occurrence
Possible Indication of Error on MYTHIC 22
action
WBC Cold Agglutinin
(+)
Cause :
high IgM level may lower RBC and increase
MCV.
Indication :
↑MCV, ↓
HCT, N1 &/or N2 &/or L1 &/or
HL flags.
Seek for red cell clumping
on smear.
Nucleated RBC
Erythroblastosis
Indication :
NRBC may be detected on the WBC
scattergram with N1 &/or N2 &/or L1 flags.
Unlysed RBC (+)
Cause:
in some rare instance few erythrocytes may
not be completely lysed.
Indication :
lyse-resistant RBC may be detected on
the WBC scattergram with N1 &/or N2 &/or L1
&/or HL flags.
Cryoglobulins
(+)
Cause:
In association with various pathologies
cryoglobulins cause the WBC, RBC, Plt and Hgb to
increase.
Indication
: high level of all above mentioned items
in case of myeloma, carcinoma, leukemia and other
proliferative disorders, pregnancy.
Warm the specimen up to
37°C(99°F) for 30min and
re-assay immediately after.
Indication :
aggregates may be detected on the
WBC scattergram with N1 &/or N2 &/or L1 flags.
Seek for platelet
aggregates on smear.
(+): Instrument count is affected by an increase in the result.
(-): Instrument count is affected by a decrease in the result.
(?): Instrument count is affected by either an increase or decrease in the result which is sample dependent.
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