OperationModel 2500 77
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5.3.4 Intrinsic
Overview
The intrinsic dissolution rate is defined as the dissolution rate of pure
substances under the condition of constant surface area, agitation-stirring
speed, pH and ionic-strength of the dissolution medium. See USP 30-NF 25
General Chapter <1087> for more details.
Once the Intrinsic is assembled with the test material, the assembly is then
immersed, pellet side up, in the bottom of a flat dissolution vessel.
Height setting using Intrinsic:
1 Turn the Easy Drive Lift knob about 1/2 turn following the direction of the "Released"
indicator.
2 Fully raise the drive head and turn the Easy Drive Lift knob following the direction of the
"Lock" indicator, to lock the drive head in place.
3 Position the height setting to
N eutra l
by positioning the Quick Height Adjustment block to
horizontal position. See figure below for reference.
Height adjustment block position for neutral
4 Gently slide each shaft halfway up through each spindle. If shafts are hard to to slide, a
very thin film of vacuum grease applied on the shaft (near the bottom of the spindle) will
allow it to slide smoothly.
5 Loosen the locking collar on each shaft.
6 Position each intrinsic disc inside the vessel. Lower the drive head onto the height
adjustment block and turn the drive lift knob to lock position.
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