Manuale operativo
CHORUS
Rev. 0 del 06/2012 9
1 INTRODUCTION
1.1 SAFETY INFORMATION
Before using the instrument, the operator should carefully read Chapter 2 (Safety) and note the risks
attached to operating the instrument and the necessary measures for limiting risks.
1.2 FIELD OF APPLICATION
The CHORUS
instrument is a multi parametric instrument, designed to automatically conduct serologic
tests using ready to use diagnostic devices with single doses (strips).
The available test panels are: Infectious diseases and Autoimmunity.
1.2.1 I
NFECTIOUS DISEASES
The methods applied in the serologic diagnoses of infectious diseases are EIA (Enzyme
Immunoassay) and CFT (complement fixation test).
It is possible to study the antibody response by applying the EIA method (isotypes IgG, IgM, IgA) to
many pathogen agents. The confirmation of specific antibodies in the patient’s blood is a valid way to
support and define the clinical picture.
The CFT method detects the antibodies that are able to fix the complement directed against specific
antigens. Given the particular function of the compliment in the overall picture of the immunitary
system, the complement fixation test is particularly useful, together with clinical analyses of the patient,
to identify the acute phase of an infection.
1.2.2 A
UTOIMMUNITY
The applied method is EIA (Enzyme Immunoassay).
By highlighting the various classes of auto-antibodies directed against cellular antigens and non-
cellular antigens, it is possible to assist the clinical diagnostics of a large number of systemic or organ
specific autoimmune pathologies.
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