SYSMEX XE-5000 - Possible Sample Interferences

CHAPTER 11 Technical Information
Sysmex XE-5000 Instructions for Use 11-9
Revised August 2008
11.2 Possible sample interferences
WBC
Where the following are present, the white blood cell count
may be reported falsely low.
- Leukocyte aggregation
Where the following are present, the white blood cell count
may be reported falsely high.
- Platelet aggregation
- Lyse resistant erythrocytes
- Erythroblasts(when NRBC is not analyzed)
- Erythrocyte aggregation (Cold agglutinin)
- Cryoprotein
- Cryoglobulin
- Fibrin
- Giant platelets (Platelets>1,000,000/µL)
RBC
Where the following are present, the red blood cell count may
be reported falsely low.
- Erythrocyte aggregation (Cold agglutinin)
- Microcytosis
- Fragmented erythrocytes
Where the following are present, the red blood cell count may
be reported falsely high.
- Leukocytosis (Lymphocytes>100,000/µL)
- Giant platelets (Platelets>1,000,000/µL)
HGB
Where the following are present, the blood cell count may be
reported falsely high.
- Leukocytosis (Lymphocytes>100,000/µL)
- Lipemia
- Abnormal protein
HCT
Where the following are present, the hematocrit value may be
reported falsely low.
- Erythrocyte aggregation (Cold agglutinin)
- Microcytosis
- Fragmented erythrocytes
Where the following are present, the hematocrit value may be
reported falsely high.
- Leukocytosis (Lymphocytes>100,000/µL)
- Severe diabetes
- Uremia
- Spherocytosis