July 29, 2013, 715003794 Rev. B 291
D Solvent Considerations
Introduction
Clean solvents
Clean solvents provide these benefits:
• Reproducible results
• Operation with minimal instrument maintenance
A dirty solvent can cause these conditions:
• Baseline noise and drift
• Blockage of the solvent filters with particulate matter
Warning: To avoid chemical hazards, always observe safe
laboratory practices.
Contents:
Topic Page
Introduction...................................................................................... 291
Solvent compatibility ....................................................................... 294
Solvent miscibility............................................................................ 297
Buffered solvents.............................................................................. 300
Head height ...................................................................................... 300
Solvent viscosity............................................................................... 300
Mobile phase solvent degassing ...................................................... 301
Wavelength selection ....................................................................... 302
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