Roche Diagnostics
112 Instructions for Use · Version 13.0
4 Theoretical foundations cobas b 123 POC system
Parameters and calculations
[6] National Committee on Clinical Laboratory Standards, Defintions of Quantities and
Conventions Related to Blood pH and Gas Analysis, NCCLS Document C12-A;
Approved Standard (1994), Vol. 14 No. 11.
[7] Thode, J. Fogh-Andersen, N. Wimberley, P.D. Moller Sorensen, A. Siggaard-
Andersen, O.: Relation between pH and ionized calcium in vitro and in vivo man.
Scand. J. Clin. Lab. Invest., 43. Suppl. 165, 79–82, 1983
[8] Thomas, Lothar: Labor und Diagnose: Indikation und Bewertung von
Laborbefunden für die medizinische Diagnostik; 7. Auflage, Frankfurt am Main: TH-
Books- Verl.- Ges. 2008, S. 677 f.
[9] Despopoulos, Agamemmon; Silbernagel, Stefan: Color Atlas of Physiology, Georg
Thieme Verlag Stuttgart, New York 1991, 4th edition, p. 60
[10] Burtis, Carl A,; Ashwood, Edward R.: Tietz Textbook of Clinical Chemistry, 4th
edition, W.B. Saunders Company, 2006; p. 992
[11] Fazekas, A. S.; Funk, G.-Ch.; Klobassa, D. S.; Rüther, H., Ziegler, I., Zander, R.,
Semmelrock, H.-J.: Evaluation of 36 formulas for calculating plasma osmolality;
Intensive Care Med (2013), 39: 302–308
[12] Alan E. Jones; Nathan I. Shapiro; Stephen Trzeciak; Ryan C, Arnold; Heather A.
Claremont; Jeffrey A. Kline: Lactate clearance vs central venous oxygen saturation as
goals of early sepsis therapy. a randomized clinical trial; JAMA, February 24. 2010,
Vol. 303, No. 8, 739–746
[13] H. Bryant Nguyen; Manisha Loomba; James J. Yang; Gordon Jacobsen; Kant Shah;
Ronny M. Otero; Arturo Suarez; Hemal Parekh; Anja Jaehne; Emanuel P. Rivers:
Early lactate clearance is associated with biomarkers of inflammation, coagulation,
apoptosis, organ dysfunction and mortality in severe sepsis and septic shock; Journal
of Inflammation 2010. 7:6