Roche Diagnostics
Instructions for Use · Version 13.0 149
cobas b 123 POC system 6 Measurement
Interferences
Substances with effect on tHb, SO
2
, bilirubin and Hb derivatives
0.5 mmol/L
Cl
-(2)
104.8 3.5 ± 0.9 4.3
Sodium chloride
45 mmol/L
(1)
Hct
(3)
43.3% -9.4± 0.2% 3%
20 mmol/L
Hct
(3)
45.6% -3.8 ± 0.3% 3%
10 mmol/L
Hct
(2)(3)
45.6% -0.9 ± 0.2% 3%
Sodium bromide
37.5 mmol/L
(1)
Cl
-
Cl
-
Cl
-
Glu
80.09
103.7
119.01
4.0
147.99 ± 24.5
111.1 ± 12.0
147.04 ± 17.87
0.5 ± 0.3
4.0
4.2
4.77
0.5
18.75 mmol/L
Glu
(2)
4.0 0.2 ± 0.1 0.5
1.0 mmol/L
(1)
Cl
-(2)
105.5 4.0 ± 0.4 4.3
Sodium iodide
2.99 mmol/L
(1)
Cl
-
Cl
-
Cl
-
80.63
102.3
122.55
26.74 ± 7.25
35.8 ± 13.8
55.71 ± 19.11
4.0
4.2
4.9
0.45 mmol/L
Cl
-(2)
105.3 1.3 ± 0.7 4.3
Sodium nitroprusside 4 mmol/L
Cl
-
102.5 10.4 ± 6.7 4.2
1 mmol/L
Cl
-(2)
104.4 3.3 ± 1.6 4.3
Sodium perchlorate 1.5 mmol/L
Cl
-
104.9 11.4 ± 3.8 4.3
0.375 mmol/L
Cl
-(2)
103.5 2.3 ± 0.8 4.3
Norepinephrine 0.118 mol/L Glu 4.1 -0.5 ± 0.2 0.5
0.06 mmol/L
Glu
(2)
4.5 -0.3 ± 0.1 0.5
Salicylic acid
4.34 mmol/L
(1)
Cl
-
Cl
-
Lac
79.02
117.3
104.0
15.55 ± 2.84
20.48 ± 4.77
20.3 ± 6.0
4.0
4.71
4.3
1.09 mmol/L
Cl
-(2)
103.6 1.8 ± 0.5 4.3
(1) The substance and its concentrations are recommended in Clinical and Laboratory Standards Institute. Interference testing in clinical chemistry,
CLSI document EP07-A2; Approved Guideline (2005), Vol. 25, No. 27.
(2) Within trueness specifications
(3) When determining interference for hematocrit, sample matrix modification (morphology of the erythrocytes, hemolysis, and osmosis effect) has to
be considered when adding substances. Therefore, sample modification was determined with an absolute reference measurement using
centrifugation (hemofuge), and the values determined with the cobas b 123 POC system were corrected.
Substance
Substance
concentration
Parameter
Parameter
concentration (MV)
[mmol/L]
Effect of the substance
[mmol/L]
± Trueness
[mmol/L]
Table 6-3 Substances with effect on BG, pH, ISE, Glu, Lac and Hct
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