Roche Diagnostics
148 Instructions for Use · Version 13.0
6 Measurement cobas b 123 POC system
Interferences
Substances with effect on BG, pH, ISE, Glu, Lac and Hct
pH low 7.1 tHb, HHb, O
2
Hb, COHb, MetHb, SO
2
pH low 6.7 Bili
Propofol, 2% 0.11 mg/mL tHb, HHb, O
2
Hb, COHb, MetHb, SO
2
, Bili
SMOF lipid, 20%
(1)
10 mg/mL tHb, HHb, O
2
Hb, COHb, MetHb, SO
2
, Bili
Total protein (Albumin)
(1)
12 g/dL tHb, HHb, O
2
Hb, COHb, MetHb, SO
2
, Bili
Voluven, 6%
(1)
1:1 dilution tHb, HHb, O
2
Hb, COHb, MetHb, SO
2
, Bili
(1) The substance and its concentrations are recommended in Clinical and Laboratory Standards Institute.
Interference testing in clinical chemistry, CLSI document EP07-A2; Approved Guideline (2005), Vol.
25, No. 27.
Substance Concentration Tested analyte
Table 6-2 Substances without effect on tHb, SO
2
, Hb derivatives and bilirubin
Substance
Substance
concentration
Parameter
Parameter
concentration (MV)
[mmol/L]
Effect of the substance
[mmol/L]
± Trueness
[mmol/L]
Acetylcysteine
10.2 mmol/L
(1)
Glu
Lac
4.1
5.5
-1.4 ± 0.5
-1.4 ± 0.3
0.5
0.7
2.55 mmol/L
Lac
(2)
5.2 -0.6 ± 0.1 0.7
1.75 mmol/L
Glu
(2)
4.0 -0.1 ± 0.1 0.5
Benzalkonium chloride 0.0285 mmol/L
Na
+
132.2 5.3 ± 0.9 2.9
0.0280 mmol/L
Na
+
Na
+
116.47
152.20
2.81 ± 0.42
4.07 ± 0.83
2.940
3.630
0.0143 mmol/L
Na
+(2)
138.4 2.1 ± 0.3 3.1
Dobutamine 0.066 mmol/L
Na
+
137.4 21.2 ± 2.3 3.1
0.05 mmol/L
Na
+(2)
138.0 1.6 ± 0.2 3.1
Glycolic acid
(hydroxyacetic acid)
13.05 mmol/L Lac 5.2 0.7 ± 0.5 0.7
2.5 mmol/L
Lac
(2)
5.4 0.4 ± 0.2 0.7
Uric acid
1.4 mmol/L
(1)
Lac 6.0 -0.9 ± 0.1 0.7
0.35 mmol/L
Lac
(2)
5.4 -0.3 ± 0.1 0.7
Hydroxycarbamide
(hydroxyurea)
2.5 mmol/L Glu
Lac
4.0
4.8
1.2 ± 0.7
-1.2 ± 0.6
0.5
0.7
0.63 mmol/L
Glu
(2)
Lac
(2)
3.8
4.5
0.1 ± 0.2
-0.4 ± 0.2
0.5
0.7
Potassium thiocyanate
6.88 mmol/L
(1)
Cl
-
Cl
-
Cl
-
Glu
107.7
79.42
119.93
4.0
176.5 ± 56.5
130.39 ± 43.09
356.92 ± 120.59
1.2 ± 0.4
4.4
4.0
4.8
0.5
3.44 mmol/L
Glu
(2)
3.9 0.4 ± 0.2 0.5
Table 6-3 Substances with effect on BG, pH, ISE, Glu, Lac and Hct
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