Complex soluons such as blood deviate slightly from Nernsan behavior due to interfering ions and
matrix eects that result in juncon potenals. By including selecvity coecients in the Nernst
equaon (Nikolsky equaon), these eects can be minimized. By characterizing the reference electrode
in dierent soluons, eects of matrix on the reference juncon potenal can also be minimized.
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i-STAT Alinity — System Operaons Manual Art: 745524-01 Rev. I Rev. Date: 02-Nov-2022