Anatel A643a - Calibration and Validation 81 of 220
RPS - June 2007 - Edition 12
Anatel Operator Manual
6 Calibration and Validation
6.1 General Information
The Anatel A643a is equipped with on-demand calibration and validation capability to ensure
the reliability of its results. Calibration assures the accuracy of instrument’s readings at regular
intervals; validation ensures the accuracy of the calibration by “challenging” it with the analysis
of a known standard. Calibration and validation data are available for viewing via a C80
Controller or through a local or network printer.
The Anatel A643a is calibrated at the factory before shipment. It is not necessary to perform a
TOC Calibration prior to placing the instrument into service.
Proper calibration of the Anatel A643a is critical to maintaining optimum instrument
performance. There are several approaches to calibration to run unknown samples and
accurately report the results. Calibration and validation involve running analyses of one or more
standards and blanks in order to determine instrumental response:
Each procedure is prompted by a series of menus and all analyses are performed
automatically. The necessary materials are available through Anatel in prepackaged
Reagent Kits.
These are intended as general instructions on the performance of the calibration and
validation procedures. Refer to the specific Standard Operating Procedure (SOP) for detailed
instructions.
TOC Calibration Select from up to three levels (250, 500 and 750 ppb) of a
sucrose standard. The procedure also allows up to three
analysis replicates per standard for maximum accuracy.
TOC Validation Perform either a single-point or multipoint validation of the
TOC calibration using using up to three levels of sucrose
validation standards.
Conductivity Calibration Performed according to the guidelines established in
USP Method <645>. The procedure uses a NIST-
traceable calibrated resistor for the determination of
meter accuracy and a NIST-traceable 100 µS/cm
conductivity standard for cell constant verification.
System Suitability Performed according to the guidelines established in
USP Method <643> using prepackaged 500 ppb sucrose
and 500 ppb 1,4-benzoquinone standards.
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